Predicting “Airborne” Influenza Viruses: (Trans-) mission Impossible?
Identifieur interne : 000C19 ( Main/Exploration ); précédent : 000C18; suivant : 000C20Predicting “Airborne” Influenza Viruses: (Trans-) mission Impossible?
Auteurs : E. M. Sorrell [Pays-Bas] ; E. J. A. Schrauwen [Pays-Bas] ; M. Linster [Pays-Bas] ; M. De Graaf [Royaume-Uni] ; S. Herfst [Pays-Bas] ; R. A. M. Fouchier [Pays-Bas]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2011.
Abstract
Repeated transmission of animal influenza viruses to humans has prompted investigation of the viral, host, and environmental factors responsible for transmission via aerosols or respiratory droplets. How do we determine – out of thousands of influenza virus isolates collected in animal surveillance studies each year – which viruses have the potential to become “airborne”, and hence pose a pandemic threat? Here, using knowledge from pandemic, zoonotic and epidemic viruses, we postulate that the minimal requirements for efficient transmission of an animal influenza virus between humans are: efficient virus attachment to (upper) respiratory tissues, replication to high titers in these tissues, and release and aerosolization of single virus particles. Investigating “airborne” transmission of influenza viruses is key to understand – and predict – influenza pandemics.
Url:
DOI: 10.1016/j.coviro.2011.07.003
PubMed: 22440921
PubMed Central: 3311991
Affiliations:
- Pays-Bas, Royaume-Uni
- Angleterre, Angleterre de l'Est, Hollande-Méridionale
- Cambridge, Rotterdam
- Université de Cambridge
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M." last="Sorrell">E. M. Sorrell</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schrauwen, E J A" sort="Schrauwen, E J A" uniqKey="Schrauwen E" first="E. J. A." last="Schrauwen">E. J. A. Schrauwen</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Linster, M" sort="Linster, M" uniqKey="Linster M" first="M." last="Linster">M. Linster</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Graaf, M" sort="De Graaf, M" uniqKey="De Graaf M" first="M." last="De Graaf">M. De Graaf</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Herfst, S" sort="Herfst, S" uniqKey="Herfst S" first="S." last="Herfst">S. Herfst</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fouchier, R A M" sort="Fouchier, R A M" uniqKey="Fouchier R" first="R. A. M." last="Fouchier">R. A. M. Fouchier</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Repeated transmission of animal influenza viruses to humans has prompted investigation of the viral, host, and environmental factors responsible for transmission via aerosols or respiratory droplets. How do we determine – out of thousands of influenza virus isolates collected in animal surveillance studies each year – which viruses have the potential to become “airborne”, and hence pose a pandemic threat? Here, using knowledge from pandemic, zoonotic and epidemic viruses, we postulate that the minimal requirements for efficient transmission of an animal influenza virus between humans are: efficient virus attachment to (upper) respiratory tissues, replication to high titers in these tissues, and release and aerosolization of single virus particles. Investigating “airborne” transmission of influenza viruses is key to understand – and predict – influenza pandemics.</p></div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Hollande-Méridionale</li></region><settlement><li>Cambridge</li><li>Rotterdam</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Sorrell, E M" sort="Sorrell, E M" uniqKey="Sorrell E" first="E. M." last="Sorrell">E. M. Sorrell</name></region><name sortKey="Fouchier, R A M" sort="Fouchier, R A M" uniqKey="Fouchier R" first="R. A. M." last="Fouchier">R. A. M. Fouchier</name><name sortKey="Herfst, S" sort="Herfst, S" uniqKey="Herfst S" first="S." last="Herfst">S. Herfst</name><name sortKey="Linster, M" sort="Linster, M" uniqKey="Linster M" first="M." last="Linster">M. Linster</name><name sortKey="Schrauwen, E J A" sort="Schrauwen, E J A" uniqKey="Schrauwen E" first="E. J. A." last="Schrauwen">E. J. A. Schrauwen</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="De Graaf, M" sort="De Graaf, M" uniqKey="De Graaf M" first="M." last="De Graaf">M. De Graaf</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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